产品简介

KB细胞系(KB Cell Line)是人口腔表皮样癌细胞(Epidermal Carcinoma of the Mouth)，最初认为这个细胞源自口腔表皮癌，但随后通过同工酶分析、HeLa标记染色体和DNA指纹分析发现，起源细胞已被HeLa污染。角蛋白阳性。有报告称，KB细胞含有人乳头状瘤病毒18 (HPV-18)序列。研究显示，KB细胞是叶酸受体(Folate Receptor，FA)高表达细胞，是叶酸靶向给药系统的理想靶细胞。

KB细胞系(KB Cell Line)为人口腔表皮样癌细胞，贴壁生长，培养条件为，10%FBS的MEM完全培养液。

包装

保存

无菌包装。完全培养液或液氮冻存。

参考文献

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2、Boshart M, et al. A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer. EMBO J. 3: 1151-1157, 1984. PubMed: 6329740

3、Salzman NP. Animal Cell Cultures. Science 133:1559-65. 1961 PubMed: 13745868

4、Eagle H, Foley GE. Cytotoxicity in human cell cultures as a primary screen for the detection of anti-tumor agents. Cancer Res. 18: 1017-1025, 1958. PubMed: 13596943

5、Foley GE, Handler AH. Differentiation of “Normal” and Neoplastic Cells Maintained in Tissue Culture by Implantation into Normal Hamsters. Proc SocExpBiol Med 94: 661-664 1957. PubMed:13431913

6、Eagle H, et al. Viral susceptibility of a human carcinoma cell (strain KB). Proc. Soc. Exp. Biol. Med. 91: 361-364, 1956. PubMed: 13322936

7、St. Geme JW, et al. Characterization of the genetic locus encoding Haemophilusinfluenzae type b surface fibrils. J. Bacteriol. 178: 6281-6287, 1996. PubMed: 8892830

8、Chang K, Pastan I. Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers. Proc. Natl. Acad. Sci. USA 93: 136-140, 1996. PubMed: 8552591

9、Lee RJ, Huang L. Folate-targeted, anionic liposome-entrapped polylysine-condensed DNA for tumor cell-specific gene transfer. J. Biol. Chem. 271: 8481-8487, 1996. PubMed: 8626549