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Cullin 3多肽

产品编号

包装

价格

   3710058-C 

0.5mg

680.00

 3710058-C1

1mg

1280.00

 3710058-C2

2mg

1980.00

产品简介

 Core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the BCR complex depends on the BTB domain-containing protein as the susbstrate recognition component. BCR(SPOP) is involved in ubiquitination of BMI1/PCGF4, H2AFY and DAXX, and probably GLI2 or GLI3. BCR(KLHL9-KLHL13) controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. Involved in ubiquitination of cyclin E and of cyclin D1 (in vitro) thus involved in regulation of G1/S transition.

 Cullin 3多肽(Cullin 3 PolypeptideCUL3为本所人工合成并纯化的Cullin 3 多肽片段,本品为干粉或水溶液。

包装 

 产品编号

 3710058-C

3710058-C1 

3710058-C2 

Cullin 3 多肽

0.5mg

1mg

2mg

说明书

1 份

保存                                                        

-20℃或以下可保存1年或以上。使用过程中可短时间保存于4℃。请勿反复冻融或于0℃以上久置。

 

更新时间:2016-05-12    浏览次数:176次
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