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T细胞免疫球蛋白粘附素3 C端多肽

产品编号

包装

价格

3710068-T

0.5mg

680.00

3710068-T1

1mg

1280.00

3710068-T2

2mg

1980.00

产品简介 

     Hepatitis A virus cellular receptor 2 (HAVCR2), formerly known as T cell immunoglobulin and mucin domain-3 (TIM-3), is a transmembrane glycoprotein expressed on the surface of terminally differentiated Th1 cells but not on Th2 cells. It was the first surface molecule that specifically identifies Th1 cells in both mice and human. Recently, identification of Galectin-9 as a ligand for TIM-3 has established the TIM-3-Galectin-9 pathway as an important regulator of Th1 immunity and tolerance induction. Engagement of Tim-3 by its ligand galectin-9 negatively regulates IFN-gamma secretion and influences the ability to induce T cell tolerance in both mice and man. It suggests a novel paradigm in which dysregulation of the TIM-3-galectin-9 pathway could underlie chronic autoimmune disease states, such as multiple sclerosis. Recent work has explored the role of TIM-3 in systemic lupus erythematosus (SLE), and their results indicate that TIM-3 may represent a novel target for the treatment of SLE. Numerous studies have demonstrated that Tim-3 influences autoimmune diseases, including diabetes and multiple sclerosis, and its role in other inflammatory diseases including allergies and cancer is beginning to become clear. In tumor rejection model, soluble form of Tim-3 (sTim-3) significantly impaired T cell antitumor immunity, evidenced by decreased antitumor CTL activity and reduced amount of tumor-infiltrating lymphocytes in tumor. sTim-3 as an immunoregulatory molecule that may be involved in the negative regulation of T cell-mediated immune response. 

    T细胞免疫球蛋白粘附素3 C端多肽(T Cell Immunoglobulin Mucin 3 Polypeptide C TerminalTIM-3为本所人工合成并纯化的T细胞免疫球蛋白粘附素3C端多肽片段,本品为干粉或水溶液。 

包装 

 产品编号

3710068-T

3710068-T1

3710068-T2

 T细胞免疫球蛋白粘附素3 C端多肽

0.5mg

1mg

2mg

说明书

1 份

保存                                                        

-20℃或以下可保存1年或以上。使用过程中可短时间保存于4℃。请勿反复冻融或于0℃以上久置。

更新时间:2016-05-12    浏览次数:250次
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