销售热线:13355177528  QQ号:2216266870
站内搜索:
您目前所在的位置:首页 >> 产品目录 >> 抗体 >> 多克隆抗体
产品搜索:
兔抗NF-κB1多克隆抗体

产品编号

包装

价格

1010078-N

100ug

680.00

1010078-N1

200ug

1280.00

1010078-N2

1mg

4800.00

产品简介

Transcription factors of the nuclear factor κ B (NF-κB)/Rel family play a pivotal role in inflammatory and immune responses (1,2). There are five family members in mammals: RelA, c-Rel, RelB, NF-κB1 (p105/p50), and NF-κB2 (p100/p52). Both p105 and p100 are proteolytically processed by the proteasome to produce p50 and p52, respectively. Rel proteins bind p50 and p52 to form dimeric complexes that bind DNA and regulate transcription. In unstimulated cells, NF-κB is sequestered in the cytoplasm by IκB inhibitory proteins (3-5). NF-κB-activating agents can induce the phosphorylation of IκB proteins, targeting them for rapid degradation through the ubiquitin-proteasome pathway and releasing NF-κB to enter the nucleus where it regulates gene expression (6-8). NIK and IKKα (IKK1) regulate the phosphorylation and processing of NF-κB2 (p100) to produce p52, which is then translocated to the nucleus.Following IKK-mediated phosphorylation of p105 NF-κB at multiple sites (Ser921, 923, 927, and 932) on its carboxy-terminus, SCF/β-TrCP mediated processing produces the 50 kDa active form p50.

兔抗NF-κB1多克隆抗体(Rabbit Anti-NF-κB1 Polyclonal AntibodyNF-κB1)是以NF-κB1的合成多肽与KLH偶联,免疫健康家兔,获得高效价免疫血清,再经蛋白A亲和柱层析纯化,溶于PBS pH7.4)中,蛋白浓度1mg/ml,可广泛用于NF-κB1的各种免疫检测分析。

包装

产品编号

1010078-N

1010078-N1

1010078-N2

兔抗NF-κB1多克隆抗体

0.5mg

1mg

2mg

说明书

1

保存

-20℃或以下可保存1年或以上。使用过程中可短时间保存于4℃。请勿反复冻融或于0℃以上久置。

使用说明

本产品经一抗稀释液稀释后可用于ELISA1:1000),IHC1:200),IP1:50),WB1:300)等免疫检测分析。

更新时间:2017-09-08    浏览次数:1418次
Copyright@2009 北京翰谱医药生物研究所 All Rights Reserved
销售热线:13355177528 QQ号:2216266870 E-mail:hapmed@163.com 地址:北京市昌平区沙河镇昌平路97号新元科技园5幢5-542 京ICP备09031681号
京ICP备2010042718号 技术支持:才高八斗 网站在线客服
网站在线客服